Factor VII Variant Database

c.529G>A

p.Gly177Arg (Legacy AA No. 117)

Mutation Type:

Point

Domain:

EGF2

Codon Change:

AGG > GGG

Mutation Effect:

Missense

Location:

Exon(6)

No of bases:

No. of patients reported:

Patient Information : Show

Case ID	FVII:C%	FVII:Ag(%)	Inheritance	Additional Variants in Case	Reported Clinical Severity	Comments	Reference
TF-Unknown	TF-Human	TF-Rabbit
693	<1			UK	Homozygous	-	Mild		Jayandharan et al 2007

Residue Information :

	Name	Type	Cyclic	Size	Hydrophobicity	Charge
Wild Type	Gly	aliphatic	acyclic	small	hydrophobic	neutral
Mutated	-	-	-	-	-	-

Substitution Analysis :

Structural Implications :

Gly177 is shown below as a red sphere.

Gly177 is a buried residue(the surface accessibility from the FVII structure is 1).

Gly177 is in a random coil area of the FVII structure (the DSSP assignment from the modelled FVII domains is T).

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Factor VII Gene (F7)

Variant Database

In Depth Variant Analysis: c.529G>A (p.Gly177Arg)

Patient Information : Show

Residue Information :

Substitution Analysis :

Structural Implications :

Structure details

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