Factor VII Variant Database

c.303G>C

p.Trp101Cys (Legacy AA No. 41)

Mutation Type:

Point

Domain:

Gla

Codon Change:

TGC > TGG

Mutation Effect:

Missense

Location:

Exon(4)

No of bases:

No. of patients reported:

Patient Information : Show

Case ID	FVII:C%	FVII:Ag(%)	Inheritance	Additional Variants in Case	Reported Clinical Severity	Comments	Reference
TF-Unknown	TF-Human	TF-Rabbit
427	UK			UK	Heterozygous	-	Unknown		Chu et al 2002

Residue Information :

	Name	Type	Cyclic	Size	Hydrophobicity	Charge
Wild Type	Trp	aromatic	cyclic	large	hydrophobic	neutral
Mutated	-	-	-	-	-	-

Substitution Analysis :

Structural Implications :

Trp101 is shown below as a red sphere.

Trp101 is an exposed residue(the surface accessibility from the FVII structure is 6).

Trp101is in a region of secondary structure within the FVII domains (the DSSP assignment from the modelled FVII domains is H).

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Factor VII Gene (F7)

Variant Database

In Depth Variant Analysis: c.303G>C (p.Trp101Cys)

Patient Information : Show

Residue Information :

Substitution Analysis :

Structural Implications :

Structure details

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